Proton therapy is effective in treating many types of cancerous and non-cancerous tumors.

The greater precision of proton therapy spares healthy organs, allowing a higher dose of radiation to be delivered to base-of-skull tumors. The higher the dose, the better the tumor can be controlled.1

Treatable base-of-skull tumors include chordomas and chondrosarcomas. Tumors in the base-of-skull region are difficult to treat because they are often close to critical structures such as the brainstem, spinal cord, and optic nerves. The location of these tumors often makes surgical removal difficult and limits the dose of radiation that can be delivered. Proton therapy can be particularly appropriate for these tumors because it minimizes radiation exposure to surrounding healthy tissue.

Since these tumors are found at a shallow depth, proton therapy is able to deliver radiation precisely to the tumor with low risk of affecting tissues of the brain and spinal cord.1 The greater precision of proton therapy spares more healthy tissues while effectively treating base-of-skull tumors.

Reference

1. Rutz HP, Weber DC, Sugahara S, et al. Extracranial chordoma: outcome in patients treated with function-preserving surgery followed by spot-scanning photon beam irradiation. Int J Radiat Oncol Biol Phys. 2007;67(2):512-520.



PROTON THERAPY RESEARCH


Proton Therapy is an innovative means of cancer treatment that delivers radiation at exact depths to precisely target tumors. Much of the radiation is deposited exactly at the tumor site and then stops, reducing excess radiation to healthy tissue compared to X-rays. X-rays release their maximum dose of radiation quickly after penetrating the skin, potentially damaging healthy tissue and organs on their way to the tumor and as they pass through your body beyond the tumor.

Click on the sources to the right to find out more about proton therapy and the research conducted.

Skull Base


Ares C, Hug EB, Lomax AJ, et al. Effectiveness and safety of spot scanning proton radiation therapy for chordomas and chondrosarcomas of the skull base: first long-term report. Int J Radiat Oncol Biol Phys. 2009;75(4):1111-1118.

Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19386442

Noël G, Feuvret L, Calugaru V, et al. Chordomas of the base of the skull and upper cervical spine. One hundred patients irradiated by a 3D conformal technique combining photon and proton beams. Acta Oncol. 2005;44(7):700-708.

Abstract: http://www.ncbi.nlm.nih.gov/pubmed/16227160

Munzenrider JE, Liebsch NJ. Proton therapy for tumors of the skull base. Strahlenther Onkol. 1999;175(Suppl 2):57-63.

Abstract: http://www.ncbi.nlm.nih.gov/pubmed/10394399

Bugoci DM, Girvigian MR, Chen JC, Miller MM, Rahimian J. Photon-based fractionated stereotactic radiotherapy for postoperative treatment of skull base chordomas. Am J Clin Oncol. 2013; 36(4):404-410.

Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22772429

Pommier P, Liebsch NJ, Deschler DG, et al. Proton beam radiation therapy for skull base adenoid cystic carcinoma. Arch Otolaryngol Head Neck Surg. 2006;132(11):1242-1249.

Abstract: http://www.ncbi.nlm.nih.gov/pubmed/17116822

Weber DC, Schneider R, Goitein G, et al. Spot scanning-based proton therapy for intracranial meningioma: long-term results from the Paul Scherrer Institute. Int J Radiat Oncol Biol Phys. 2012;83(3):865-871.

Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22138457

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