ProCure's mission is to improve the lives of patients with cancer by increasing access to proton therapy.
News and Research

New Jersey

How far have we come in the battle against cancer?
Reducing Secondary Side Effects for the Long-term Care of Cancer Patients
A Brave Boy – And A Town-Full Of Supporters
Listen to Dr. Jae Lee, and his patient, Carolyn Graham, discuss proton therapy (Audio)
14 Ways to Make Cancer Patients More Comfortable
After Surviving Cancer, Norwood Resident Gives Back
Dr. Soffen on Breast Cancer Awareness Month 1450 WCTC (Audio)
Long Island Cancer Survivor Celebrates Life, Shares Journey
Dr. Soffen discusses Prostate Cancer Awareness 1450 WCTC (Audio)
Hillsborough Dad Shares Story Of Survival From Prostate Cancer
Many faces of Peter Lanigan: Cancer survivor, coach, official, Hall of Famer
Local woman benefits from proton therapy for cancer treatment
ProCure teams with New York cancer to offer proton therapy
Northwell and ProCure NJ establish clinical affiliation...
Dr. Henry Tsai from ProCure Celebrates 3000th Patient Milestone on 1450 WCTC (Audio)
ProCure Proton Therapy Center NJ Honors 3,000th Patient to Complete Treatment
ProCure recognizes five-year prostate cancer-free patients during awareness month
Proton therapy holds promise as best new treatment option for childhood cancers
Woodbridge Teen Makes Incredible Comeback After Brain Cancer
Teenage Cancer Patient Travels to Disney World for the Trip of a Lifetime
Surviving, and Thriving, in the Face of Prostate Cancer
Interview with Dr. Brian Chon - Pediatric Cancer - 1450 WCTC (Audio)
Teenage Cancer Patient Travels to Disney World for the Trip of a Lifetime
Pencil beam scanning: The proton therapy innovation bringing...
Heartbeats: Teaming up to fight colorectal cancer
ProCure Proton Therapy New Jersey Celebrates Five Years of Service to Cancer Community
Bellmoreite fights cancer with alternative treatment
Washington Twp. woman triumphs in third breast cancer bout
Nurse's devoted care to babies continued during proton therapy
Four years cancer-free from proton therapy
Interview with Dr. Henry Tsai - Breast Cancer Awareness Month on 1450 WCTC (Audio)
Finding 'yes:' My journey with breast cancer
Victory over prostate cancer for this North Brunswick man
ProCure's inaugural class of prostate cancer patient graduates
Finding empowerment through breast cancer
Proton Therapy: Game Changer for Breast Cancer?
ProCures inaugural class of prostate cancer patient graduates remail cancer free...
Surviving — and thriving — thanks to proton therapy
Teeing off on prostate cancer
Interview with Dr. Henry Tsai - Prostate Cancer Awareness Month on 1450 WCTC (Audio)
Former Marine tackles a new battlefield: Prostate cancer
Proton therapy: Less invasive, less available?
My life was saved thanks to a news story on Mako
Runner fights against cancer … and for quality of life
A meditation on living with Stage 4 breast cancer
Seven year old residents raise money for Pediatric unit
Dr. Henry Tsai from ProCure Celebrates 2000th Patient Milestone on 1450 WCHE (Audio)
Dr. Henry Tsai from ProCure Celebrates 2000th Patient Milestone on 1450 WCTC (Audio)
When I was 31 years old, my doctor told me I had only 3 years left to live
Radiation center celebrates milestone, Brentwood prostate cancer patient finds healing
The gift of life
Prostate Cancer: Advice for men at-risk for or facing a diagnosis
5 Minutes with cancer aurvivor Mary Maddox
Proton therapy for breast cancer: A promising treatment path
Leading-edge prostate cancer treatment close to home
A cancer survivor shares 5 ways to get better healthcare
Hunterdon man has led life defined by a legacy of service
Gala to fight pediatric cancer is most successful to date
Former marine finds cancer treatment with help of military friends
Retired police chief praises proton therapy for prostate cancer
MSKCC Oncologist's Mission: Curing Hodgkin Lymphoma with fewer long-term side effects
Dr. Brian Chon from ProCure Proton Therapy Center on 1450 WCTC (Audio)
Healthcare facilities offer variety of breast cancer services
Freehold physicist advocates for proton-based prostate treatment
Fresh Outlook: Breast cancer awareness month (Video)
After protons, NYC woman is ready to graduate, start her career
This isn't a film screening: Bar Sitton (Hebrew)
Dr. Henry Tsai ProCure Proton Therapy Center on 1450 WCTC (Audio)
One woman's answer to cancer: fight, research, laugh
Girl, interrupted: Living with a recurring brain tumor
Experiences shape career path of nurse from Lebanon
North Bergen runner took cancer head-on thanks to unconventional treatment
Allstate, Hugs for Brady Foundation bring joy to cancer facility
Kids were huge motivator for teacher, young mother during cancer treatments
Proton Therapy: A better way to destroy tumors and spare normal tissue
Protons only hope for NY woman fighting late-effect cancer from photon radiation
Treating Breast Cancer while Sparing the Heart
Educating Others About Oral Cancer is new Mission for Cancer Survivor
Targeted Treatment Gives Readington Woman Second Chance
Cancer Survivor Touts Use of Proton Therapy
Boonton Resident Advocates for Early Cancer Screenings
Checking in with warrior Kris Neves
Victor and Zelda Lawson's Journey Back to Life (Video)
Prostate Cancer Patient, Matt Iacobazzo, Talks About Why he Chose ProCure (Video)
ProCure in Somerset has Joined Forces with Hugs for Brady Foundation
Denville College Student Perseveres Despite Cancer Treatments
Proton Therapy Center in Franklin is Gaining Traction in Cancer Treatment
Hugs for Brady Foundation Starts New Chapter in Fight Against Pediatric Cancer
Advancements in Radiation Therapy
Concordia Coach Tyler Jones Raises Prostate Cancer Awareness
Positive Steps
ProCure’s Involvement in Treating the Hearts, Minds and Souls of Medical Travelers
Iselin Woman Plans Wedding, Fights Cancer
Discovering the Power of Proton Therapy through an ESPN Interview (Audio clip/.mp3)
Managing Prostate Cancer Recurrence after Surgery (Audio clip/.mp3)
Finding the Right Approach and a Healing Environment (Audio clip/.mp3)
A Roadblock leads a Patient to the Right Therapeutic Choice (Audio clip/.mp3)
Diagnosis Prompted by a Wife’s Observation: Uncovering a Cyst (Audio clip/.mp3)
Finding a Better Alternative for X-ray Therapy: Spousal Support (Audio clip/.mp3)
Celebrating Nurse Innovators in Patient Care
Katonah Man Undergoes Proton Therapy To Fight Rare Cancer
Researchers Gather To Discuss Therapy Alternative For Breast Cancer
Growth in Proton Therapy Increases Demand for Well-Trained Staff
3-point Plan Protects Medical Practice Technology in Disasters
P-Cure Opens New Assembly Center
Sparta man beats cancer with proton therapy
Proton therapy: Radiation without the side effects?
Cancer facility breaks ground in Franklin
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Proton Therapy News

Proton Therapy Targets Cancer Anywhere in the Body (Video)
Proton Clinical Research Center of the Shandong Cancer Hospital...
Cancer: Proton therapy has fewer side effects than X-ray radiation
Proton therapy for cancer lowers risk of side effects
(Washington University School of Medicine in St. Louis)
Montefiore Study May Help Establish Patient Criteria for Proton Therapy
Point of View: Health insurers need to be accountable
Why randomized trials for proton therapy are difficult to complete
How proton therapy attacks cancer
Physicians from Leading U.S. Cancer Centers Address Cost & Coverage Issues...
NAPT Calls Attention to Promising Clinical Trial Results...
Proton therapy may be better option for elderly patients with esophageal cancer
Proton therapy for prostate cancer is advantageous to imrt according to new study
Proton therapy lowers treatment side effects in pediatric head and neck cancer patients
Proton Therapy in Hodgkin Lymphoma Yields Favorable Acute Toxicity Profile
ASTRO updates insurance coverage recommendations for proton therapy
Business People: Local firms' hirings and promotions (Dr. Harrell and Dr. Yeh)
Proton International and Univ. of Alabama to develop state's first proton treatment center
More men with early prostate cancer are choosing to avoid treatment
Effects of proton therapy on pulmonary function in Hodgkin Lymphoma patients
Proton-beam therapy for cancer gets renewed attention
New mom first patient to undergo proton therapy at Orlando Health
Postoperative intensity-modulated proton therapy for head and neck adenoid cystic carcinoma
Use of proton therapy for prostate cancer has doubled
Chesapeake Energy : Remembering an Oklahoma icon
State to look at insurance coverage for proton therapy
Proton radiotherapy may be feasible option for pediatric brain tumor
Proton Therapy experts convene in New Orleans and via live streaming
23 Truths about breast cancer that survivors want you to know
IBA sees barriers falling as proton beams tested in more cancers
BlueBEAR HPC Service Supports Proton Therapy Research
Varian Signs Contracts to Equip Two National Proton Therapy Centers in England
Gov. Fallin (Oklahoma) signs Rep. Marian Cooksey's proposal boosting Proton Therapy
New study finds that proton therapy has fewer side effects in esophageal cancer patients
Oklahoma House approves proton therapy cancer patient bill
Patients must battle more than cancer for their lives
MEVION S250 Gets Approval to Treat Cancer Patients in Canada
University of Oklahoma Proton Therapy System Enters Clinical Commissioning
US Proton Therapy Market Opportunity Analysis
Treating Breast Cancer while Sparing the Heart
Global Proton Therapy Market 2014-2018
Insurance Debate Snares Prostate Study
BlueCross BlueShield, Provision Remain Split on Proton Therapy
Cincinnati Children's To Add 200 Butler County Jobs
Cancer-Zapping Proton Therapy Only Suitable for Rare Patients
Cancer-fighting Device Company Mevion Medical Files for a $69 million IPO
IBA and Philips Join Forces to Advance Diagnosis and Treatment of Cancer
$100M Proton Therapy Center Closer to Reality for Miami Township
How to Pay for Only the Health Care You Want
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Chuong MD, Hartsell W, Larson G, Tsai H, Laramore GE, Rossi CJ, Wilkinson JB, Kaiser A, Vargas C. Minimal toxicity after proton beam therapy for prostate and pelvic nodal irradiation: results from the proton collaborative group REG001-09 trial. Acta Oncol. 2017 Oct 14:1-7. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29034790 Hoppe BS, Harris S, Rhoton-Vlasak A, Bryant C, Morris CG, Dagan R, Nichols RC, Mendenhall WM, Henderson RH, Li Z, Mendenhall NP. Sperm preservation and neutron contamination following proton therapy for prostate cancer study. Acta Oncol. 2016 Jul 15:1-4. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/27420031 Underwood T, Giantsoudi D, Moteabbed M, Zietman A, Efstathiou J, Paganetti H, Lu HM. Can We Advance Proton Therapy for Prostate? Considering Alternative Beam Angles and Relative Biological Effectiveness Variations When Comparing Against Intensity Modulated Radiation Therapy. Int J Radiat Oncol Biol Phys. 2016 May 1;95(1):454-64. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/27084660 Vargas C, Fryer A, Mahajan C, et al. Dose-volume comparison of proton therapy and intensity-modulated radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2008;70(3):744-751. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/17904306 Trofimov A, Nguyen PL, Coen JJ, et al. Radiotherapy treatment of early-stage prostate cancer with IMRT and protons: a treatment planning comparison. Int J Radiat Oncol Biol Phys. 2007;69(2):444-453. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/17513063 Slater JD. Clinical applications of proton radiation treatment at Loma Linda University: review of a fifteen-year experience. Technol Cancer Res Treat. 2006;5(2):81-89. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/16551128 Zietman AL, DeSilvio ML, Slater JD, et al. Comparison of conventional-dose vs high-dose conformal radiation therapy in clinically localized adenocarcinoma of the prostate: a randomized controlled trial. JAMA. 2005;294(10):1233-1239. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/16160131 Zietman AL, Bae K, Slater JD, et al. Randomized trial comparing conventional-dose with high-dose conformal radiation therapy in early-stage adenocarcinoma of the prostate: long-term results from Proton Radiation Oncology Group/American College of Radiology 95-09. J Clin Oncol. 2010;28(7):1106-1111. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20124169 back to top


Hug EB. Proton Therapy for Primary Breast Cancer. Breast Care (Basel). 2018 Jul;13(3):168-172. doi: 10.1159/000489893. Epub 2018 Jun 15. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30069176 MacDonald SM, Patel SA, Hickey S, et al. Proton therapy for breast cancer after mastectomy: early outcomes of a prospective clinical trial. Int J Radiat Oncol Biol Phys. 2013;86(3):484-490. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/23523326 Moon SH, Shin KH, Kim TH, et al. Dosimetric comparison of four different external beam partial breast irradiation techniques: three-dimensional conformal radiotherapy, intensity-modulated radiotherapy, helical tomotherapy, and proton beam therapy. Radiother Oncol. 2009;90(1):66-73. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18992950 Ares C, Khan S, MacArtain AM, et al. Postoperative proton radiotherapy for localized and locoregional breast cancer: potential for clinically relevant improvements? Int J Radiat Oncol Biol Phys. 2010;76(3):685-697. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19615828 MacDonald SM, Jimenez R, Paetzold P, et al. Proton radiotherapy for chest wall and regional lymphatic radiation; dose comparisons and treatment delivery. Radiat Oncol. 2013;8:71. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/23521809 Darby SC, Ewertz M, McGale P, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med. 2013;368(11):987-998. Abstract: http://www.nejm.org/doi/full/10.1056/NEJMoa1209825 Nilsson G, Holmberg L, Garmo H, et al. Distribution of coronary artery stenosis after radiation for breast cancer. J Clin Oncol. 2012;30(4):380-386. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22203772 Harris EER, Correa C, Hwang W-T, et al. Late cardiac mortality and morbidity in early-stage breast cancer patients after breast-conservation treatment. J Clin Oncol. 2006;24(25):4100-4106. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/16908933 back to top


Chang JY, Zhang X, Wang X, et al. Significant reduction of normal tissue dose by proton radiotherapy compared with three-dimensional conformal or intensity-modulated radiation therapy in stage I or stage III non–small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2006;65(4):1087-1096. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/16682145 Chang JY, Komaki R, Lu C, et al. Phase 2 study of high-dose proton therapy with concurrent chemotherapy for unresectable stage III nonsmall cell lung cancer. Cancer. 2011;117(20):4707-4713. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21437893 Sejpal S, Komaki R, Tsao A, et al. Early findings on toxicity of proton beam therapy with concurrent chemotherapy for nonsmall cell lung cancer. Cancer. 2011;117(13):3004-3013. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21264827 back to top


Clayton B. Hess, Daniel J. Indelicato, Arnold C. Paulino, William F. Hartsell, Christine E. Hill-Kayser, Stephanie M. Perkins, Anita Mahajan, Nadia N. Laack, Ralph P. Ermoian, Andrew L. Chang, Suzanne L. Wolden, Victor S. Mangona, Young Kwok, John C. Breneman, John P. Perentesis, Sara L. Gallotto, Elizabeth A. Weyman, Benjamin V. M. Bajaj, Miranda P. Lawell, Beow Y. Yeap and Torunn I. Yock. Front. Oncol. 24 May 2018. Abstract: https://www.frontiersin.org/articles/10.3389/fonc.2018.00165/full Kevin B, M. Fatih O, Rona S, Anita M, Arnold C. P, Adekunle A, Robert D and Murali C. RO-11 Decreased Incidence of Hypothyroidism After Caraniospinal Irradiation (CSI) with Proton Therapy (PRT) in Patients with Medulloblastoma. Neuro Oncol. (2016) 18 (suppl 3): iii161. doi: 10.1093/neuonc/now082.11 Abstract: http://neuro-oncology.oxfordjournals.org/content/18/suppl_3/iii161.2.full Leiser D, Calaminus G, Malyapa R, Bojaxhiu B, Albertini F, Kliebsch U, Mikroutsikos L, Morach P, Bolsi A, Walser M, Timmermann B, Lomax T, Schneider R, Weber DC, et al. Tumour control and Quality of Life in children with rhabdomyosarcoma treated with pencil beam scanning proton therapy. Radiother Oncol. 2016 May 28. pii: S0167-8140(16)31116-1. doi: 10.1016/j.radonc.2016.05.013. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/27247053 Wray J, Flampouri S, Slayton W, Joyce M, Sandler E, Morris CG, Li Z, Indelicato DJ, Mendenhall NP1,2, Hoppe BS1,2. Proton Therapy for Pediatric Hodgkin Lymphoma. Pediatr Blood Cancer. 2016 May 3. doi: 10.1002/pbc.26044. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/27149120 Kahalley LS, Ris MD, Grosshans DR, Okcu MF, Paulino AC, Chintagumpala M, Moore BD, Guffey D, Minard CG, Stancel HH, Mahajan A. Comparing Intelligence Quotient Change After Treatment With Proton Versus Photon Radiation Therapy for Pediatric Brain Tumors. J Clin Oncol. 2016 Apr 1;34(10):1043-9. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26811522 Sands SA. Proton Beam Radiation Therapy: The Future May Prove Brighter for Pediatric Patients With Brain Tumors. J Clin Oncol. 2016 Apr 1;34(10):1024-6. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26811526 Yock TI, Yeap BY, Ebb DH, Weyman E, Eaton BR, Sherry NA, Jones RM, MacDonald SM, Pulsifer MB, Lavally B, Abrams AN, Huang MS, Marcus KJ, Tarbell NJ. Long-term toxic effects of proton radiotherapy for paediatric medulloblastoma: a phase 2 single-arm study. Lancet Oncol. 2016 Mar;17(3):287-98. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26830377 Hattangadi JA, Rombi B, Yock TI, et al. Proton radiotherapy for high-risk pediatric neuroblastoma: early outcomes and dose comparison. Int J Radiat Oncol Biol Phys. 2012;83(3):1015-1022. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22138463 Lin R, Hug EB, Schaefer RA, Miller DW, Slater JM, Slater JD. Conformal proton radiation therapy of the posterior fossa: a study comparing protons with three-dimensional planned photons in limiting dose to auditory structures. Int J Radiat Oncol Biol Phys. 2000;48(4):1219-1226. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/11072181 Yock T, Schneider R, Friedmann A, Adams J, Fullerton B, Tarbell N. Proton radiotherapy for orbital rhabdomyosarcoma: clinical outcome and a dosimetric comparison with photons. Int J Radiat Oncol Biol Phys. 2005;63(4):1161-1168. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/15950401 Merchant TE, Hua CH, Shukla H, Ying X, Nill S, Oelfke U. Proton versus photon radiotherapy for common pediatric brain tumors: comparison of models of dose characteristics and their relationship to cognitive function. Pediatr Blood Cancer. 2008;51(1):110-117. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18306274 Kozak KR, Adams J, Krejcarek SJ, Tarbell NJ, Yock TI. A dosimetric comparison of proton and intensity-modulated photon radiotherapy for pediatric parameningeal rhabdomyosarcomas. Int J Radiat Oncol Biol Phys. 2009;74(1):179-186. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19019562 Beltran C, Roca M, Merchant TE. On the benefits and risks of proton therapy in pediatric craniopharyngioma. Int J Radiat Oncol Biol Phys. 2012;82(2):e281-e287. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21570209 Childs SK, Kozak KR, Friedmann AM, et al. Proton radiotherapy for parameningeal rhabdomyosarcoma: clinical outcomes and late effects. Int J Radiat Oncol Biol Phys. 2012;82(2):635-642. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21377294 Rutz HP, Weber DC, Goitein G, et al. Postoperative spot-scanning proton radiation therapy for chordoma and chondrosarcoma in children and adolescents: initial experience at Paul Scherrer Institute. Int J Radiat Oncol Biol Phys. 2008;71(1):220-225. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18068310 Hug EB, Sweeney RA, Nurre PM, Holloway KC, Slater JD, Munzenrider JE. Proton radiotherapy in management of pediatric base of skull tumors. Int J Radiat Oncol Biol Phys. 2002;52(4):1017-1024. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/11958897 Hug EB, Muenter MW, Archambeau JO, et al. Conformal proton radiation therapy for pediatric low-grade astrocytomas. Strahlenther Onkol. 2002;178(1):10-17. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/11977386 Merchant TE, Kiehna EN, Li C, Xiong X, Mulhern RK. Radiation dosimetry predicts IQ after conformal radiation therapy in pediatric patients with localized ependymoma. Int J Radiat Oncol Biol Phys. 2005;63(5):1546-1554. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/16115736 Merchant TE, Rose SR, Bosley C, Wu S, Xiong X, Lustig RH. Growth hormone secretion after conformal radiation therapy in pediatric patients with localized brain tumors. J Clin Oncol. 2011;29(36):4776-4780. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22042949 Kuhlthau KA, Pulsifer MB, Yeap BY, et al. Prospective study of health-related quality of life for children with brain tumors treated with proton radiotherapy. J Clin Oncol. 2012;30(17):2079-2086. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22565004 Brown AP, Barney CL, Grosshans DR, et al. Proton beam craniospinal irradiation reduces acute toxicity for adults with medulloblastoma. Int J Radiat Oncol Biol Phys. 2013;86(2):277-284. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/23433794 back to top

Brain and Skull Base

Mizumoto M, Yamamoto T, Ishikawa E, Matsuda M, Takano S, Ishikawa H, Okumura T, Sakurai H, Matsumura A, Tsuboi K. Proton beam therapy with concurrent chemotherapy for glioblastoma multiforme: Comparison of nimustine hydrochloride and temozolomide. J Neurooncol. 2016 Aug 17. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/27535747 Shih HA, Sherman JC, Nachtigall LB, Colvin MK, Fullerton BC, Daartz J, Winrich BK, Batchelor TT, Thornton LT, Mancuso SM, Saums MK, Oh KS, Curry WT, Loeffler JS, Yeap BY. Proton therapy for low-grade gliomas: Results from a prospective trial. Cancer. 2015 May 15;121(10):1712-9. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25585890 Ares C, Hug EB, Lomax AJ, et al. Effectiveness and safety of spot scanning proton radiation therapy for chordomas and chondrosarcomas of the skull base: first long-term report. Int J Radiat Oncol Biol Phys. 2009;75(4):1111-1118. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19386442 Noël G, Feuvret L, Calugaru V, et al. Chordomas of the base of the skull and upper cervical spine. One hundred patients irradiated by a 3D conformal technique combining photon and proton beams. Acta Oncol. 2005;44(7):700-708. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/16227160 Munzenrider JE, Liebsch NJ. Proton therapy for tumors of the skull base. Strahlenther Onkol. 1999;175(Suppl 2):57-63. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/10394399 Bugoci DM, Girvigian MR, Chen JC, Miller MM, Rahimian J. Photon-based fractionated stereotactic radiotherapy for postoperative treatment of skull base chordomas. Am J Clin Oncol. 2013; 36(4):404-410. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22772429 Pommier P, Liebsch NJ, Deschler DG, et al. Proton beam radiation therapy for skull base adenoid cystic carcinoma. Arch Otolaryngol Head Neck Surg. 2006;132(11):1242-1249. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/17116822 Dennis ER, Bussière MR, Niemierko A, et al. A comparison of critical structure dose and toxicity risks in patients with low grade gliomas treated with IMRT versus proton radiation therapy. Technol Cancer Res Treat. 2013;12(1):1-9. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22775339 Fogh SE, Andrews DW, Glass J, et al. Hypofractionated stereotactic radiation therapy: an effective therapy for recurrent high-grade gliomas. J Clin Oncol. 2010;28(18):3048-3053. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20479391 Weber DC, Schneider R, Goitein G, et al. Spot scanning-based proton therapy for intracranial meningioma: long-term results from the Paul Scherrer Institute. Int J Radiat Oncol Biol Phys. 2012;83(3):865-871. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22138457 Ronson BB, Schulte RW, Han KP, Loredo LN, Slater JM, Slater JD. Fractionated proton beam irradiation of pituitary adenomas. Int J Radiat Oncol Biol Phys. 2006;64(2):425-434. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/16257131 Miralbell R, Lomax A, Cella L, Schneider U. Potential reduction of the incidence of radiation-induced second cancers by using proton beams in the treatment of pediatric tumors. Int J Radiat Oncol Biol Phys. 2002;54(3):824-829. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/12377335 Chung CS, Yock TI, Nelson K, Xu Y, Keating NL, Tarbell NJ. Incidence of second malignancies among patients treated with proton versus photon radiation. Int J Radiat Oncol Biol Phys. 2013;87(1):46-52. Abstract: http://www.redjournal.org/article/S0360-3016%2813%2900459-8/abstract?cc=y?cc=y Merchant TE, Hua CH, Shukla H, Ying X, Nill S, Oelfke U. Proton versus photon radiotherapy for common pediatric brain tumors: comparison of models of dose characteristics and their relationship to cognitive function. Pediatr Blood Cancer. 2008;51(1):110-117. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18306274 back to top


Takada A, Nakamura T, Takayama K, Makita C, Suzuki M, Azami Y, Kato T, Tsukiyama I, Hareyama M, Kikuchi Y, Daimon T, Toyomasu Y, Ii N, Nomoto Y, Sakuma H, Fuwa N. Preliminary treatment results of proton beam therapy with chemoradiotherapy for stage I-III esophageal cancer. Cancer Med. 2016 Mar;5(3):506-15. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26806272 Zhang X, Zhao K, Guerrero TM, et al. Four-dimensional computed tomography-based treatment planning for intensity-modulated radiation therapy and proton therapy for distal esophageal cancer. Int J Radiat Oncol Biol Phys. 2008;72(1):278-287. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18722278 Komatsu S, Hori Y, Fukumoto T, Murakami M, Hishikawa Y, Ku Y. Surgical spacer placement and proton radiotherapy for unresectable hepatocellular carcinoma. World J Gasteroenterol. 2010;16(14):1800-1803. Abstract: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852832/ Meyer JJ, Czito BG, Willett CG. Particle radiation therapy for gastrointestinal malignancies. Gastrointest Cancer Res. 2007; 1(suppl 2):S50-S59. Abstract: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666838/ back to top

Head and Neck

Chan AW, Liebsch NJ. Proton radiation therapy for head and neck cancer. J Surg Oncol. 2008;97(8):697-700. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18493920 Steneker M, Lomax A, Schneider U. Intensity modulated photon and proton therapy for the treatment of head and neck tumors. Radiother Oncol. 2006;80(2): 263-267. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/16916557 van de Water TA, Lomax AJ, Bijl HP, et al. Potential benefits of scanned intensity-modulated proton therapy versus advanced photon therapy with regard to sparing of the salivary glands in oropharyngeal cancer. Int J Radiat Oncol Biol Phys. 2011;79(4):1216-1224. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20732761 Kandula S, Zhu X, Garden AS, et al. Spot-scanning beam proton therapy vs intensity-modulated radiation therapy for ipsilateral head and neck malignancies: a treatment planning comparison. Med Dosim. 2013;38(4):390-394. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/23916884 Chung CS, Yock TI, Nelson K, Xu Y, Keating NL, Tarbell NJ. Incidence of second malignancies among patients treated with proton versus photon radiation. Int J Radiat Oncol Biol Phys. 2013;87(1): 46-52. Abstract: http://www.redjournal.org/article/s0360-3016%2813%2900459-8/abstract Cahlon O, Chon B, Lee N, Yeh B, Hug E, Schreuder N. Feasibility of using 3D conformal uniform scanning proton beam therapy for locally advanced oropharyngeal carcinoma requiring bilateral neck irradiation. Int J Radiat Oncol Biol Phys. 2013;87(2):S744-S745. Abstract: http://www.redjournal.org/article/S0360-3016%2813%2902643-6/fulltext#sec1 van der Laan HP, van de Water TA, van Herpt HE, et al. The potential of intensity-modulated proton radiotherapy to reduce swallowing dysfunction in the treatment of head and neck cancer: a planning comparative study. Acta Oncol. 2013;52(3):561-569. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22708528 Zenda S, Kohno R, Kawashima M, et al. Proton beam therapy for unresectable malignancies of the nasal cavity and paranasal sinuses. Int J Radiat Oncol Biol Phys. 2011;81(5):1473-1478. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20961697 Fukumitsu N, Okumura T, Mizumoto M, et al. Outcome of T4 (International Union Against Cancer Staging System, 7th edition) or recurrent nasal cavity and paranasal sinus carcinoma treated with proton beam. Int J Radiat Oncol Biol Phys. 2012;83(2):704-711. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22099036 back to top


Hrbacek J, Mishra KK, Kacperek A, Dendale R, Nauraye C, Auger M, Herault J, Daftari IK, Trofimov AV, Shih HA, Chen YL, Denker A, Heufelder J, Horwacik T, Swakon J, Hoehr C, Duzenli C, Pica A, Goudjil F, Mazal A, Thariat J, Weber DC. Practice Patterns Analysis of Ocular Proton Therapy Centers: The International OPTIC Survey. >Int J Radiat Oncol Biol Phys. 2016 May 1;95(1):336-43. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/27084651 Gragoudas ES, Li W, Goitein M, Lane AM, Munzenrider JE, Egan KM. Evidence-based estimates of outcome in patients irradiated for intraocular melanoma. Arch Ophthalmol. 2002;120(12):1665-1671. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/12470140 Yock T, Schneider R, Friedman A, Adams J, Fullerton B, Tarbell N. Proton radiotherapy for orbital rhabdomyosarcoma: clinical outcome and a dosimetric comparison with photons. Int J Radiat Oncol Biol Phys. 2005;63(4):1161-1168. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/15950401 back to top


Weber DC, Trofimov AV, Delaney TF, Bortfeld T. A treatment planning comparison of intensity modulated photon and proton therapy for paraspinal sarcomas. Int J Radiat Oncol Biol Phys. 2004;58(5):1596-1606. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/15050341 back to top


Nobuhiro Uwa, Tomonori Terada, Takeshi Mohri, Yoshitane Tsukamoto, Hiroyuki Futani, Yusuke Demizu, Tomoaki Okimoto, Masafumi Sakagami. An unexpected skin ulcer and soft tissue necrosis after the nonconcurrent combination of proton beam therapy and pazopanib: A case of myxofibrosarcoma. Auris Nasus Larynx. 2016 Aug 11. pii: S0385-8146(16)30224-3. doi: 10.1016/j.anl.2016.07.016. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/27523716 Verma V, Simone CB 2nd, Wahl AO, Beriwal S, Mehta MP. Proton radiotherapy for gynecologic neoplasms. Acta Oncol. 2016 Aug 8:1-9. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/27500710 Chhabra A, Langen K, Mehta MP, et al. An overview of modern proton therapy. Chin Clin Oncol. 2016 May 31. pii: cco.2016.05.06. doi: 10.21037/cco.2016.05.06. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/27334460 Shah A, Ricci KI, Efstathiou JA. Beyond a moonshot: insurance coverage for proton therapy. Lancet Oncol. 2016 May;17(5):559-61 Abstract: http://www.ncbi.nlm.nih.gov/pubmed/27301029 Verma V, Mishra MV, Mehta MP. A systematic review of the cost and cost-effectiveness studies of proton radiotherapy. Cancer. 2016 May 15;122(10):1483-501. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26828647 back to top

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