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Clinical Trials

Since proton therapy was approved by the U.S. Food and Drug Administration to treat patients in 1988, the medical community has continued to conduct research on the use of protons in treating different types of cancer through clinical trials. Over the years, many patients have volunteered to take part in these clinical trials to help find improvements in fighting cancer with proton therapy.

As a dedicated provider of proton therapy, ProCure is always looking for ways to improve the lives of patients with cancer. Our team has made a commitment to participate in clinical trials to further our knowledge of the benefits of proton therapy in many tumor types.

What are clinical trials?

Clinical trials are research studies that involve people. They are the final step in a long process that begins with research in a lab. Each study answers a specific set of scientific questions and explores better ways to prevent, screen for, diagnose or treat a disease. Most treatments used today are the results of past clinical trials.

What are protocols?

For every clinical trial, a protocol, or action plan, is prepared prior to conducting the trial. The protocol describes in detail what will be done in the study, how it will be conducted, and why each part of the study is necessary. Each study has its own rules about who can participate. For instance, some studies need patients with a certain condition, some need healthy people, some need just men or just women etc.

Clinical Trials at this ProCure Center

ProCure Proton Therapy Center in Oklahoma City is currently participating in the clinical trials listed below.

  • REG001-09/NCT01255748: Patients Treated with Proton Therapy
    A registry trial to collect and analyze information from patients treated with proton therapy.
    Learn more »

  • GU002-10/NCT01230866: Low Risk Prostate Cancer (standard fractionation vs. hypo-fractionation)
    A phase III prospective randomized trial comparing the effects (good and bad) on patients with low risk prostate cancer by comparing the standard number of radiation treatments (44 treatments over 8½-9 weeks) with a short course of radiation (5 treatments over 1-2 weeks) using higher radiation dose per treatment to see if the effects of the treatments are similar or better.
    Learn more »

  • GU003-10/NCT01492972: Intermediate Risk Prostate Cancer
    A phase III trial comparing the effects (good and bad) of hypofraction proton therapy (28 treatments) with or without androgen suppression therapy on patients with intermediate risk prostate cancer.
    Learn more »

  • UPCC 23309/NCT01126476: Recurrent Tumors
    A study to determine the feasibility of using proton radiotherapy in recurrent malignancies. Patients with histologically confirmed, non-CNS solid malignancies who have been previously radiated and have a tumor recurrence in or near prior radiation fields can participate in the trial.
    Learn more »

  • BRE007-12/NCT01766297: Early Stage Breast Cancer
    A phase II trial comparing the effects (good and bad) on women with early stage breast cancer using proton radiation therapy.
    Learn more »

  • BRE008-12/NCT01758445: Stage III Breast Cancer
    A study to look at the rates of acute and long term adverse events of postoperative proton radiotherapy for complex loco-regional irradiation in women with loco-regionally advanced breast cancer. This study specifically includes longitudinal follow up to assess the incidence of cardiac mortality and second malignant neoplasms at 10 and 15 years following proton therapy.
    Learn more »

  • LUN005-12: A Phase I/II Study of Hypofractionated Proton Therapy for Stage II-III Non-Small Cell Lung Cancer
    A research study to compare the effects (good and bad) on subjects and their cancer using standard chemotherapy in combination with hypofractionated proton radiation therapy. Hypofractionation is a technique that delivers higher daily doses of radiation over a shorter
    period of time.
    Learn more »

Search Clinical Trials

You can search for more clinical trials by visiting

Participate in a Trial

If you are interested in participating in a trial listed above, please contact a member of our research team and we will help you with next steps.

Tisha Adams, Clinical Research Coordinator
Phone (405) 773-6775
Email address: